Is There Really Chronic Lyme Disease?

There is an abundant, growing body of research evidencing persistent infection after standard courses of antibiotic treatment for Lyme Disease, often leading to chronic, debilitating illness. Lyme patients desperately need research to develop more effective treatments.

Health Care Costs, Utilization and Patterns of Care following Lyme Disease

An Optimized SYBR Green I/PI Assay for Rapid Viability Assessment and Antibiotic Susceptibility Testing for Borrelia burgdorferi 

Drug Combinations against Borrelia burgdorferi Persisters In Vitro: Eradication Achieved by Using Daptomycin, Cefoperazone and Doxycycline

Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library

Counterpoint: Long-Term Antibiotic Therapy Improves Persistent Symptoms Associated with Lyme Disease

Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice

Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection

Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro

Researchers at Brown University poke holes in the Klempner study, which the IDSA uses to justify denying long-term treatment to Lyme patients

Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection

Eradication of Biofilm-Like Microcolony – Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime

List of 700 articles citing chronic infection associated with tick-borne disease compiled by Dr. Robert Bransfield

A Drug Combination Screen Identifies Drugs Active against Amoxicillin-induced Round Bodies of Borrelia burgdorferi Persisters from an FDA Drug Library